Faculty Profile

News and Awards
Publications
  • A DNA Translocation Velocity Controller in a Viral Packaging Motor J. M. Tsay, J. Sippy, D. del Toro, B. T. Andrews, B. Draper, V. Rao, C. Catalano, M. Feiss, D. E. Smith, submitted (PDF file)
  • Biophysics of Knotting, D. Meluzzi, D. E. Smith, G. Arya, Annual Reviews of Biophysics, in press (PDF file)
  • The Q motif of a viral packaging motor governs its force generation and communicates ATP recognition to DNA interaction J. M. Tsay, J. Sippy, M. Feiss, D. E. Smith, Proceedings of the National Academy of Sciences USA 104, 16868 (2009) (PDF file)
  • Portal motor velocity and internal force resisting viral DNA packaging in bacteriophage phi29 J. P. Rickgauer, D. Fuller, S. Grimes, P. Jardine, D. Anderson, D. E. Smith, Biophysical Journal 94, 159 (2008) (PDF file)
  • Single bacteriophage T4 DNA packaging motors exhibit large force generation, high velocity, and dynamic variability D. N. Fuller, D. M. Raymer, V. Kottadiel, V. B. Rao, and D. E. Smith, Proceedings of the National Academy of Sciences USA 104, 16868 (2007) (PDF file)
Douglas Smith

Douglas Smith

Ph. D., Stanford University, 1999

Contact

Web: Homepage
Office: NSB 2115
Phone: 858-534-5241
Secondary Phone: 822-1379 or 822-4836

Research Statement

- Mechanical manipulation and imaging of single DNA molecules
- Viral DNA packaging in bacteriophages phi29, lambda, and T4
- Function of ATP-dependent molecular motors
- Single polymer dynamics (polymer physics, DNA properties, rheology)
- Chromatin assembly and structure
- Enzyme mediated DNA looping
- Restriction endonuclease function
- Physics of knot formation